Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

X-linked neutropenia (XLN) is caused by activating mutations in the Wiskott-Aldrich syndrome protein (WASP) that result in aberrant autoinhibition. Although patients with XLN appear to have only defects in myeloid lineages, we hypothesized that activating mutations of WASP are likely to affect the i...

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Detalles Bibliográficos
Autores principales: Westerberg, Lisa S., Meelu, Parool, Baptista, Marisa, Eston, Michelle A., Adamovich, David A., Cotta-de-Almeida, Vinicius, Seed, Brian, Rosen, Michael K., Vandenberghe, Peter, Thrasher, Adrian J., Klein, Christoph, Alt, Frederick W., Snapper, Scott B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882832/
https://www.ncbi.nlm.nih.gov/pubmed/20513746
http://dx.doi.org/10.1084/jem.20091245

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