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Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations

OBJECTIVES: We characterized pairwise and higher order patterns of non-nucleoside reverse transcriptase inhibitor (NNRTI)-selected mutations because multiple mutations are usually required for clinically significant resistance to second-generation NNRTIs. PATIENTS AND METHODS: We analysed viruses fr...

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Detalles Bibliográficos
Autores principales:	Reuman, Elizabeth C., Rhee, Soo-Yon, Holmes, Susan P., Shafer, Robert W.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882873/ https://www.ncbi.nlm.nih.gov/pubmed/20462946 http://dx.doi.org/10.1093/jac/dkq140

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