Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin

BACKGROUND: Autism is a complex polygenic neurodevelopmental disorder characterized by deficits in communication and social interactions as well as specific stereotypical behaviors. Both genetic and environmental factors appear to contribute to the pathogenesis of autism. Accumulating data including...

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Autores principales: Gupta, Sudhir, Samra, Daljeet, Agrawal, Sudhanshu
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883089/
https://www.ncbi.nlm.nih.gov/pubmed/20393790
http://dx.doi.org/10.1007/s10875-010-9402-9
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author Gupta, Sudhir
Samra, Daljeet
Agrawal, Sudhanshu
author_facet Gupta, Sudhir
Samra, Daljeet
Agrawal, Sudhanshu
author_sort Gupta, Sudhir
collection PubMed
description BACKGROUND: Autism is a complex polygenic neurodevelopmental disorder characterized by deficits in communication and social interactions as well as specific stereotypical behaviors. Both genetic and environmental factors appear to contribute to the pathogenesis of autism. Accumulating data including changes in immune responses, linkage to major histocompatibility complex antigens, and the presence of autoantibodies to neural tissues/antigens suggest that the immune system plays an important role in its pathogenesis. SUMMARY: In this brief review, we discuss the data regarding changes in both innate and adaptive immunity in autism and the evidence in favor of the role of the immune system, especially of maternal autoantibodies in the pathogenesis of a subset of patients with autism. The rationale for possible therapeutic use of intravenous immunoglobulin is also discussed.
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spelling pubmed-28830892010-06-21 Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin Gupta, Sudhir Samra, Daljeet Agrawal, Sudhanshu J Clin Immunol Article BACKGROUND: Autism is a complex polygenic neurodevelopmental disorder characterized by deficits in communication and social interactions as well as specific stereotypical behaviors. Both genetic and environmental factors appear to contribute to the pathogenesis of autism. Accumulating data including changes in immune responses, linkage to major histocompatibility complex antigens, and the presence of autoantibodies to neural tissues/antigens suggest that the immune system plays an important role in its pathogenesis. SUMMARY: In this brief review, we discuss the data regarding changes in both innate and adaptive immunity in autism and the evidence in favor of the role of the immune system, especially of maternal autoantibodies in the pathogenesis of a subset of patients with autism. The rationale for possible therapeutic use of intravenous immunoglobulin is also discussed. Springer US 2010-04-15 2010 /pmc/articles/PMC2883089/ /pubmed/20393790 http://dx.doi.org/10.1007/s10875-010-9402-9 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Gupta, Sudhir
Samra, Daljeet
Agrawal, Sudhanshu
Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin
title Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin
title_full Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin
title_fullStr Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin
title_full_unstemmed Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin
title_short Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin
title_sort adaptive and innate immune responses in autism: rationale for therapeutic use of intravenous immunoglobulin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883089/
https://www.ncbi.nlm.nih.gov/pubmed/20393790
http://dx.doi.org/10.1007/s10875-010-9402-9
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