Finding the middle ground: how kinetochores power chromosome congression

Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome co...

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Detalles Bibliográficos
Autores principales: Kops, Geert J. P. L., Saurin, Adrian T., Meraldi, Patrick
Formato: Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2010
Materias:
Multi-author Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883098/
https://www.ncbi.nlm.nih.gov/pubmed/20232224
http://dx.doi.org/10.1007/s00018-010-0321-y
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author Kops, Geert J. P. L.
Saurin, Adrian T.
Meraldi, Patrick
author_facet Kops, Geert J. P. L.
Saurin, Adrian T.
Meraldi, Patrick
author_sort Kops, Geert J. P. L.
collection PubMed
description Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.
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spelling pubmed-28830982010-06-21 Finding the middle ground: how kinetochores power chromosome congression Kops, Geert J. P. L. Saurin, Adrian T. Meraldi, Patrick Cell Mol Life Sci Multi-author Review Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore. SP Birkhäuser Verlag Basel 2010-03-16 2010 /pmc/articles/PMC2883098/ /pubmed/20232224 http://dx.doi.org/10.1007/s00018-010-0321-y Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Multi-author Review
Kops, Geert J. P. L.
Saurin, Adrian T.
Meraldi, Patrick
Finding the middle ground: how kinetochores power chromosome congression
title Finding the middle ground: how kinetochores power chromosome congression
title_full Finding the middle ground: how kinetochores power chromosome congression
title_fullStr Finding the middle ground: how kinetochores power chromosome congression
title_full_unstemmed Finding the middle ground: how kinetochores power chromosome congression
title_short Finding the middle ground: how kinetochores power chromosome congression
title_sort finding the middle ground: how kinetochores power chromosome congression
topic Multi-author Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883098/
https://www.ncbi.nlm.nih.gov/pubmed/20232224
http://dx.doi.org/10.1007/s00018-010-0321-y
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