D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO)

D-serine is an endogenous N-methyl-D-aspartate (NMDA) receptor coagonist. It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase (DAO), the major D-serine degradative enzyme. Ca...

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Detalles Bibliográficos
Autores principales: Sikka, Pilleriin, Walker, Rosie, Cockayne, Rebecca, Wood, Matthew JA, Harrison, Paul J, Burnet, Philip WJ
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883191/
https://www.ncbi.nlm.nih.gov/pubmed/20091774
http://dx.doi.org/10.1002/jnr.22332

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