A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan

A sensitive, precise, specific, linear and stability indicating isocratic HPLC method was developed for the analysis of related substances in zolmitriptan. The potential known related substances are (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one (impurity I) and (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-...

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Detalles Bibliográficos
Autores principales: Vijayakumar, E. K. S., Samel, M. A., Bhalekar, S. B., Pakhale, S. M.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883213/
https://www.ncbi.nlm.nih.gov/pubmed/20582203
http://dx.doi.org/10.4103/0250-474X.62252
Descripción
Sumario:A sensitive, precise, specific, linear and stability indicating isocratic HPLC method was developed for the analysis of related substances in zolmitriptan. The potential known related substances are (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one (impurity I) and (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one (impurity II). The method can be used for the detection and quantification of known and unknown impurities and degradants in the drug substance zolmitriptan during routine analysis and also for stability studies in view of its capability to separate degradation products.

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