A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan

A sensitive, precise, specific, linear and stability indicating isocratic HPLC method was developed for the analysis of related substances in zolmitriptan. The potential known related substances are (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one (impurity I) and (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-...

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Autores principales: Vijayakumar, E. K. S., Samel, M. A., Bhalekar, S. B., Pakhale, S. M.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883213/
https://www.ncbi.nlm.nih.gov/pubmed/20582203
http://dx.doi.org/10.4103/0250-474X.62252
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author Vijayakumar, E. K. S.
Samel, M. A.
Bhalekar, S. B.
Pakhale, S. M.
author_facet Vijayakumar, E. K. S.
Samel, M. A.
Bhalekar, S. B.
Pakhale, S. M.
author_sort Vijayakumar, E. K. S.
collection PubMed
description A sensitive, precise, specific, linear and stability indicating isocratic HPLC method was developed for the analysis of related substances in zolmitriptan. The potential known related substances are (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one (impurity I) and (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one (impurity II). The method can be used for the detection and quantification of known and unknown impurities and degradants in the drug substance zolmitriptan during routine analysis and also for stability studies in view of its capability to separate degradation products.
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spelling pubmed-28832132010-06-25 A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan Vijayakumar, E. K. S. Samel, M. A. Bhalekar, S. B. Pakhale, S. M. Indian J Pharm Sci Short Communication A sensitive, precise, specific, linear and stability indicating isocratic HPLC method was developed for the analysis of related substances in zolmitriptan. The potential known related substances are (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one (impurity I) and (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one (impurity II). The method can be used for the detection and quantification of known and unknown impurities and degradants in the drug substance zolmitriptan during routine analysis and also for stability studies in view of its capability to separate degradation products. Medknow Publications 2010 /pmc/articles/PMC2883213/ /pubmed/20582203 http://dx.doi.org/10.4103/0250-474X.62252 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Vijayakumar, E. K. S.
Samel, M. A.
Bhalekar, S. B.
Pakhale, S. M.
A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan
title A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan
title_full A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan
title_fullStr A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan
title_full_unstemmed A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan
title_short A New Stability Indicating HPLC Method for Related Substances in Zolmitriptan
title_sort new stability indicating hplc method for related substances in zolmitriptan
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883213/
https://www.ncbi.nlm.nih.gov/pubmed/20582203
http://dx.doi.org/10.4103/0250-474X.62252
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