Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

Glaucoma is one of the leading causes of bilateral blindness affecting nearly 8 million people worldwide. Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) and is often associated with elevated intraocular pressure (IOP). However, patients with normal tension glaucoma...

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Detalles Bibliográficos
Autores principales: Chi, Zai-Long, Akahori, Masakazu, Obazawa, Minoru, Minami, Masayoshi, Noda, Toru, Nakaya, Naoki, Tomarev, Stanislav, Kawase, Kazuhide, Yamamoto, Tetsuya, Noda, Setsuko, Sasaoka, Masaki, Shimazaki, Atsushi, Takada, Yuichiro, Iwata, Takeshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883340/
https://www.ncbi.nlm.nih.gov/pubmed/20388642
http://dx.doi.org/10.1093/hmg/ddq146

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