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The nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells

Microsatellite instability is a key mechanism of colon carcinogenesis. We have previously studied mutations within a (CA)13 microsatellite using an enhanced green fluorescent protein (EGFP)-based reporter assay that allows the distinction of replication errors and mismatch repair (MMR) activity. Her...

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Detalles Bibliográficos
Autores principales:	Campregher, Christoph, Scharl, Theresa, Nemeth, Manuela, Honeder, Clemens, Jascur, Thomas, Boland, C. Richard, Gasche, Christoph
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883347/ https://www.ncbi.nlm.nih.gov/pubmed/20421367 http://dx.doi.org/10.1093/hmg/ddq175

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