An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits

Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect health. However, the genetic variants identified so far only explain a small pro...

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Detalles Bibliográficos
Autores principales: Hsu, Yi-Hsiang, Zillikens, M. Carola, Wilson, Scott G., Farber, Charles R., Demissie, Serkalem, Soranzo, Nicole, Bianchi, Estelle N., Grundberg, Elin, Liang, Liming, Richards, J. Brent, Estrada, Karol, Zhou, Yanhua, van Nas, Atila, Moffatt, Miriam F., Zhai, Guangju, Hofman, Albert, van Meurs, Joyce B., Pols, Huibert A. P., Price, Roger I., Nilsson, Olle, Pastinen, Tomi, Cupples, L. Adrienne, Lusis, Aldons J., Schadt, Eric E., Ferrari, Serge, Uitterlinden, André G., Rivadeneira, Fernando, Spector, Timothy D., Karasik, David, Kiel, Douglas P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883588/
https://www.ncbi.nlm.nih.gov/pubmed/20548944
http://dx.doi.org/10.1371/journal.pgen.1000977

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