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Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

BACKGROUND: XIAP (X-linked inhibitor of apoptosis protein) is an anti-apoptotic protein exerting its activity by binding and suppressing caspases. As XIAP is overexpressed in several tumours, in which it apparently contributes to chemoresistance, and because its activity in vivo is antagonised by se...

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Detalles Bibliográficos
Autores principales:	Lecis, D, Drago, C, Manzoni, L, Seneci, P, Scolastico, C, Mastrangelo, E, Bolognesi, M, Anichini, A, Kashkar, H, Walczak, H, Delia, D
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883696/ https://www.ncbi.nlm.nih.gov/pubmed/20461078 http://dx.doi.org/10.1038/sj.bjc.6605687

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