The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells

Overexpression of cyclooxygenase-2 (COX-2) and elevated levels of its enzymatic product prostaglandin E2 (PGE(2)) occur in the majority of colorectal cancers and play important roles in colorectal tumorigenesis. However, despite the established prosurvival role of PGE(2) in cancer, the underlying me...

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Detalles Bibliográficos
Autores principales: Greenhough, Alexander, Wallam, Catherine A., Hicks, Diane J., Moorghen, Moganaden, Williams, Ann C., Paraskeva, Chris
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883743/
https://www.ncbi.nlm.nih.gov/pubmed/20348947
http://dx.doi.org/10.1038/onc.2010.94

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