Cargando…
Role of Hsp90 in Biogenesis of the β-Cell ATP-sensitive Potassium Channel Complex
The pancreatic β-cell ATP-sensitive potassium (K(ATP)) channel is a multimeric protein complex composed of four inwardly rectifying potassium channel (Kir6.2) and four sulfonylurea receptor 1 (SUR1) subunits. K(ATP) channels play a key role in glucose-stimulated insulin secretion by linking glucose...
Autores principales: | Yan, Fei-Fei, Pratt, Emily B., Chen, Pei-Chun, Wang, Fang, Skach, William R., David, Larry L., Shyng, Show-Ling |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883939/ https://www.ncbi.nlm.nih.gov/pubmed/20427569 http://dx.doi.org/10.1091/mbc.E10-02-0116 |
Ejemplares similares
-
Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels
por: Martin, Gregory M., et al.
Publicado: (2013) -
Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in K(ATP) channels
por: Pratt, Emily B., et al.
Publicado: (2012) -
N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP(2)
por: Pratt, Emily B., et al.
Publicado: (2011) -
Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating
por: Martin, Gregory M, et al.
Publicado: (2017) -
A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP(2)-Dependent Gating
por: Bushman, Jeremy D., et al.
Publicado: (2013)