Flux balance analysis accounting for metabolite dilution

Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required...

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Detalles Bibliográficos
Autores principales: Benyamini, Tomer, Folger, Ori, Ruppin, Eytan, Shlomi, Tomer
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884546/
https://www.ncbi.nlm.nih.gov/pubmed/20398381
http://dx.doi.org/10.1186/gb-2010-11-4-r43
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author Benyamini, Tomer
Folger, Ori
Ruppin, Eytan
Shlomi, Tomer
author_facet Benyamini, Tomer
Folger, Ori
Ruppin, Eytan
Shlomi, Tomer
author_sort Benyamini, Tomer
collection PubMed
description Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions.
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spelling pubmed-28845462010-06-15 Flux balance analysis accounting for metabolite dilution Benyamini, Tomer Folger, Ori Ruppin, Eytan Shlomi, Tomer Genome Biol Method Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions. BioMed Central 2010 2010-04-16 /pmc/articles/PMC2884546/ /pubmed/20398381 http://dx.doi.org/10.1186/gb-2010-11-4-r43 Text en Copyright ©2010 Benyamini et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Benyamini, Tomer
Folger, Ori
Ruppin, Eytan
Shlomi, Tomer
Flux balance analysis accounting for metabolite dilution
title Flux balance analysis accounting for metabolite dilution
title_full Flux balance analysis accounting for metabolite dilution
title_fullStr Flux balance analysis accounting for metabolite dilution
title_full_unstemmed Flux balance analysis accounting for metabolite dilution
title_short Flux balance analysis accounting for metabolite dilution
title_sort flux balance analysis accounting for metabolite dilution
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884546/
https://www.ncbi.nlm.nih.gov/pubmed/20398381
http://dx.doi.org/10.1186/gb-2010-11-4-r43
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AT folgerori fluxbalanceanalysisaccountingformetabolitedilution
AT ruppineytan fluxbalanceanalysisaccountingformetabolitedilution
AT shlomitomer fluxbalanceanalysisaccountingformetabolitedilution

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