Cargando…
Crystal structure of HIV-1 Tat complexed with human P-TEFb
Regulation of the expression of the human immunodeficiency virus (HIV) genome is accomplished in large part by controlling transcription elongation. The viral protein Tat hijacks the host cell's RNA polymerase II elongation control machinery through interaction with the positive transcription e...
Autores principales: | Tahirov, Tahir H., Babayeva, Nigar D., Varzavand, Katayoun, Cooper, Jeffrey J., Sedore, Stanley C., Price, David H. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885016/ https://www.ncbi.nlm.nih.gov/pubmed/20535204 http://dx.doi.org/10.1038/nature09131 |
Ejemplares similares
-
Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR
por: Sedore, Stanley C., et al.
Publicado: (2007) -
The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK
por: Krueger, Brian J., et al.
Publicado: (2010) -
Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat
por: Muniz, Lisa, et al.
Publicado: (2010) -
The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
por: Schulze-Gahmen, Ursula, et al.
Publicado: (2013) -
A real-time view of the TAR:Tat:P-TEFb complex at HIV-1 transcription sites
por: Molle, Dorothée, et al.
Publicado: (2007)