Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments

Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replicatio...

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Autores principales: Stow, Nigel D., Evans, Vanessa C., Matthews, David A.
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2009
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885023/
https://www.ncbi.nlm.nih.gov/pubmed/19088274
http://dx.doi.org/10.1099/vir.0.006353-0
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author Stow, Nigel D.
Evans, Vanessa C.
Matthews, David A.
author_facet Stow, Nigel D.
Evans, Vanessa C.
Matthews, David A.
author_sort Stow, Nigel D.
collection PubMed
description Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.
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spelling pubmed-28850232010-07-06 Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments Stow, Nigel D. Evans, Vanessa C. Matthews, David A. J Gen Virol Animal Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles. Society for General Microbiology 2009-01 /pmc/articles/PMC2885023/ /pubmed/19088274 http://dx.doi.org/10.1099/vir.0.006353-0 Text en Copyright © 2009, SGM http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal
Stow, Nigel D.
Evans, Vanessa C.
Matthews, David A.
Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
title Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
title_full Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
title_fullStr Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
title_full_unstemmed Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
title_short Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
title_sort upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885023/
https://www.ncbi.nlm.nih.gov/pubmed/19088274
http://dx.doi.org/10.1099/vir.0.006353-0
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