Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein

The cellular DEAD-box protein DDX3 was recently shown to be essential for hepatitis C virus (HCV) replication. Prior to that, we had reported that HCV core binds to DDX3 in yeast-two hybrid and transient transfection assays. Here, we confirm by co-immunoprecipitation that this interaction occurs in...

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Detalles Bibliográficos
Autores principales: Angus, Allan G. N., Dalrymple, David, Boulant, Steeve, McGivern, David R., Clayton, Reginald F., Scott, Martin J., Adair, Richard, Graham, Susan, Owsianka, Ania M., Targett-Adams, Paul, Li, Kui, Wakita, Takaji, McLauchlan, John, Lemon, Stanley M., Patel, Arvind H.
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2010
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885062/
https://www.ncbi.nlm.nih.gov/pubmed/19793905
http://dx.doi.org/10.1099/vir.0.015909-0

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