Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α

The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5α molecules despite the fact that they strongl...

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Detalles Bibliográficos
Autores principales: Wood, Andrew, Webb, Benjamin L. J., Bartosch, Birke, Schaller, Torsten, Takeuchi, Yasuhiro, Towers, Greg J.
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2009
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885064/
https://www.ncbi.nlm.nih.gov/pubmed/19218217
http://dx.doi.org/10.1099/vir.0.007377-0
Descripción
Sumario:The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5α molecules despite the fact that they strongly restrict a variety of divergent lentiviruses. We also show that the human PERV A/C recombinant clone 14/220 reverse transcribes with increased efficiency in human cells, leading to significantly higher infectivity. We conclude that xenotransplantation studies should consider the danger of highly infectious TRIM5α-insensitive human-tropic PERV recombinants.

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