Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α

The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5α molecules despite the fact that they strongl...

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Autores principales: Wood, Andrew, Webb, Benjamin L. J., Bartosch, Birke, Schaller, Torsten, Takeuchi, Yasuhiro, Towers, Greg J.
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2009
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885064/
https://www.ncbi.nlm.nih.gov/pubmed/19218217
http://dx.doi.org/10.1099/vir.0.007377-0
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author Wood, Andrew
Webb, Benjamin L. J.
Bartosch, Birke
Schaller, Torsten
Takeuchi, Yasuhiro
Towers, Greg J.
author_facet Wood, Andrew
Webb, Benjamin L. J.
Bartosch, Birke
Schaller, Torsten
Takeuchi, Yasuhiro
Towers, Greg J.
author_sort Wood, Andrew
collection PubMed
description The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5α molecules despite the fact that they strongly restrict a variety of divergent lentiviruses. We also show that the human PERV A/C recombinant clone 14/220 reverse transcribes with increased efficiency in human cells, leading to significantly higher infectivity. We conclude that xenotransplantation studies should consider the danger of highly infectious TRIM5α-insensitive human-tropic PERV recombinants.
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spelling pubmed-28850642010-07-06 Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α Wood, Andrew Webb, Benjamin L. J. Bartosch, Birke Schaller, Torsten Takeuchi, Yasuhiro Towers, Greg J. J Gen Virol Animal The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5α molecules despite the fact that they strongly restrict a variety of divergent lentiviruses. We also show that the human PERV A/C recombinant clone 14/220 reverse transcribes with increased efficiency in human cells, leading to significantly higher infectivity. We conclude that xenotransplantation studies should consider the danger of highly infectious TRIM5α-insensitive human-tropic PERV recombinants. Society for General Microbiology 2009-03 /pmc/articles/PMC2885064/ /pubmed/19218217 http://dx.doi.org/10.1099/vir.0.007377-0 Text en Copyright © 2009, SGM http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal
Wood, Andrew
Webb, Benjamin L. J.
Bartosch, Birke
Schaller, Torsten
Takeuchi, Yasuhiro
Towers, Greg J.
Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α
title Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α
title_full Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α
title_fullStr Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α
title_full_unstemmed Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α
title_short Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α
title_sort porcine endogenous retroviruses perv a and a/c recombinant are insensitive to a range of divergent mammalian trim5α proteins including human trim5α
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885064/
https://www.ncbi.nlm.nih.gov/pubmed/19218217
http://dx.doi.org/10.1099/vir.0.007377-0
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