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Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets

Sterol-induced binding to Insigs in the endoplasmic reticulum (ER) allows for ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. This ubiquitination marks reductase for recognition by the ATPase VCP/p97, which mediates extraction and...

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Detalles Bibliográficos
Autores principales:	Hartman, Isamu Z., Liu, Pingsheng, Zehmer, John K., Luby-Phelps, Katherine, Jo, Youngah, Anderson, Richard G. W., DeBose-Boyd, Russell A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Protein Synthesis and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885207/ https://www.ncbi.nlm.nih.gov/pubmed/20406816 http://dx.doi.org/10.1074/jbc.M110.134213

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