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Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain

In eukaryotes, a rate-limiting step of translation initiation is recognition of the mRNA 5′ m(7)GpppN cap structure by the eukaryotic initiation factor 4F (eIF4F), a heterotrimeric complex consisting of the cap-binding protein, eIF4E, along with eIF4G, and eIF4A. The eIF4E-binding proteins (4E-BPs)...

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Detalles Bibliográficos
Autores principales:	Bidinosti, Michael, Martineau, Yvan, Frank, Filipp, Sonenberg, Nahum
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Protein Synthesis and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885220/ https://www.ncbi.nlm.nih.gov/pubmed/20424163 http://dx.doi.org/10.1074/jbc.M110.120774

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