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Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study
BACKGROUND: An interaction between genetic susceptibility and environmental factors is thought to be involved in the aetiology of type 1 diabetes. The aim of this study was to investigate maternal and neonatal risk factors for type 1 diabetes in children under 15 years old in Grampian, Scotland. MET...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885337/ https://www.ncbi.nlm.nih.gov/pubmed/20507546 http://dx.doi.org/10.1186/1471-2458-10-281 |
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author | Robertson, Lynn Harrild, Kirsten |
author_facet | Robertson, Lynn Harrild, Kirsten |
author_sort | Robertson, Lynn |
collection | PubMed |
description | BACKGROUND: An interaction between genetic susceptibility and environmental factors is thought to be involved in the aetiology of type 1 diabetes. The aim of this study was to investigate maternal and neonatal risk factors for type 1 diabetes in children under 15 years old in Grampian, Scotland. METHODS: A matched case-control study was conducted by record linkage. Cases (n = 361) were children born in Aberdeen Maternity Hospital from 1972 to 2002, inclusive, who developed type 1 diabetes, identified from the Scottish Study Group for the Care of Diabetes in the Young Register. Controls (n = 1083) were randomly selected from the Aberdeen Maternity Neonatal Databank, matched by year of birth. Exposure data were obtained from the Aberdeen Maternity Neonatal Databank. Conditional logistic regression was used to evaluate the association between various maternal and neonatal factors and the risk of type 1 diabetes. RESULTS: There was no evidence of statistically significant associations between type 1 diabetes and maternal age, maternal body mass index, previous abortions, pre-eclampsia, amniocentesis, maternal deprivation, use of syntocinon, mode of delivery, antepartum haemorrhage, baby's sex, gestational age at birth, birth order, birth weight, jaundice, phototherapy, breast feeding, admission to neonatal unit and Apgar score (P > 0.05). A significantly decreased risk of type 1 diabetes was observed in children whose mothers smoked at the booking appointment compared to those whose mothers did not, with an adjusted OR of 0.67, 95% CI (0.46, 0.99). CONCLUSIONS: This case-control study found limited evidence of a reduced risk of the development of type 1 diabetes in children whose mothers smoked, compared to children whose mothers did not. No evidence was found of a significant association between other maternal and neonatal factors and childhood type 1 diabetes. |
format | Text |
id | pubmed-2885337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28853372010-06-15 Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study Robertson, Lynn Harrild, Kirsten BMC Public Health Research article BACKGROUND: An interaction between genetic susceptibility and environmental factors is thought to be involved in the aetiology of type 1 diabetes. The aim of this study was to investigate maternal and neonatal risk factors for type 1 diabetes in children under 15 years old in Grampian, Scotland. METHODS: A matched case-control study was conducted by record linkage. Cases (n = 361) were children born in Aberdeen Maternity Hospital from 1972 to 2002, inclusive, who developed type 1 diabetes, identified from the Scottish Study Group for the Care of Diabetes in the Young Register. Controls (n = 1083) were randomly selected from the Aberdeen Maternity Neonatal Databank, matched by year of birth. Exposure data were obtained from the Aberdeen Maternity Neonatal Databank. Conditional logistic regression was used to evaluate the association between various maternal and neonatal factors and the risk of type 1 diabetes. RESULTS: There was no evidence of statistically significant associations between type 1 diabetes and maternal age, maternal body mass index, previous abortions, pre-eclampsia, amniocentesis, maternal deprivation, use of syntocinon, mode of delivery, antepartum haemorrhage, baby's sex, gestational age at birth, birth order, birth weight, jaundice, phototherapy, breast feeding, admission to neonatal unit and Apgar score (P > 0.05). A significantly decreased risk of type 1 diabetes was observed in children whose mothers smoked at the booking appointment compared to those whose mothers did not, with an adjusted OR of 0.67, 95% CI (0.46, 0.99). CONCLUSIONS: This case-control study found limited evidence of a reduced risk of the development of type 1 diabetes in children whose mothers smoked, compared to children whose mothers did not. No evidence was found of a significant association between other maternal and neonatal factors and childhood type 1 diabetes. BioMed Central 2010-05-27 /pmc/articles/PMC2885337/ /pubmed/20507546 http://dx.doi.org/10.1186/1471-2458-10-281 Text en Copyright ©2010 Robertson and Harrild; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research article Robertson, Lynn Harrild, Kirsten Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study |
title | Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study |
title_full | Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study |
title_fullStr | Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study |
title_full_unstemmed | Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study |
title_short | Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study |
title_sort | maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study |
topic | Research article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885337/ https://www.ncbi.nlm.nih.gov/pubmed/20507546 http://dx.doi.org/10.1186/1471-2458-10-281 |
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