Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrP(C) on Neuronal Cells and PrP(RES) in Infected Cell Cultures

BACKGROUND: Recent advances toward an effective therapy for prion diseases employ RNA interference to suppress PrP(C) expression and subsequent prion neuropathology, exploiting the phenomenon that disease severity and progression correlate with host PrP(C) expression levels. However, delivery of len...

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Detalles Bibliográficos
Autores principales: Pulford, Bruce, Reim, Natalia, Bell, Aimee, Veatch, Jessica, Forster, Genevieve, Bender, Heather, Meyerett, Crystal, Hafeman, Scott, Michel, Brady, Johnson, Theodore, Wyckoff, A. Christy, Miele, Gino, Julius, Christian, Kranich, Jan, Schenkel, Alan, Dow, Steven, Zabel, Mark D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885418/
https://www.ncbi.nlm.nih.gov/pubmed/20559428
http://dx.doi.org/10.1371/journal.pone.0011085

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