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Altered Retinoic Acid Metabolism in Diabetic Mouse Kidney Identified by (18)O Isotopic Labeling and 2D Mass Spectrometry

BACKGROUND: Numerous metabolic pathways have been implicated in diabetes-induced renal injury, yet few studies have utilized unbiased systems biology approaches for mapping the interconnectivity of diabetes-dysregulated proteins that are involved. We utilized a global, quantitative, differential pro...

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Detalles Bibliográficos
Autores principales: Starkey, Jonathan M., Zhao, Yingxin, Sadygov, Rovshan G., Haidacher, Sigmund J., LeJeune, Wanda S., Dey, Nilay, Luxon, Bruce A., Kane, Maureen A., Napoli, Joseph L., Denner, Larry, Tilton, Ronald G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885420/
https://www.ncbi.nlm.nih.gov/pubmed/20559430
http://dx.doi.org/10.1371/journal.pone.0011095