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Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636
The identification of potential new anti-tubercular chemotherapeutics is paramount due to the recent emergence of extensively drug-resistant strains of Mycobacterium tuberculosis (XDR-TB). Libraries of NAS-21 and NAS-91 analogues were synthesized and evaluated for their whole-cell activity against M...
Autores principales: | Bhowruth, Veemal, Brown, Alistair K., Besra, Gurdyal S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885650/ https://www.ncbi.nlm.nih.gov/pubmed/18599816 http://dx.doi.org/10.1099/mic.0.2008/017434-0 |
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