Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6

A critical step in gene therapy is the efficient transfer of genes in a cell-type and tissue specific manner. To better understand the mechanism of AAV6 transduction we used CGA combined with pathway visualization software to identify a positive correlation between AAV6 transduction and EGFR express...

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Detalles Bibliográficos
Autores principales: Weller, Melodie L., Amornphimoltham, Panomwat, Schmidt, Michael, Wilson, Paul A., Gutkind, J. Silvio, Chiorini, John A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885716/
https://www.ncbi.nlm.nih.gov/pubmed/20473307
http://dx.doi.org/10.1038/nm.2145
Descripción
Sumario:A critical step in gene therapy is the efficient transfer of genes in a cell-type and tissue specific manner. To better understand the mechanism of AAV6 transduction we used CGA combined with pathway visualization software to identify a positive correlation between AAV6 transduction and EGFR expression. Subsequent experiments suggest EGFR is necessary for vector internalization and likely functions as a co-receptor for this virus.

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