Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6

A critical step in gene therapy is the efficient transfer of genes in a cell-type and tissue specific manner. To better understand the mechanism of AAV6 transduction we used CGA combined with pathway visualization software to identify a positive correlation between AAV6 transduction and EGFR express...

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Autores principales: Weller, Melodie L., Amornphimoltham, Panomwat, Schmidt, Michael, Wilson, Paul A., Gutkind, J. Silvio, Chiorini, John A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885716/
https://www.ncbi.nlm.nih.gov/pubmed/20473307
http://dx.doi.org/10.1038/nm.2145
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author Weller, Melodie L.
Amornphimoltham, Panomwat
Schmidt, Michael
Wilson, Paul A.
Gutkind, J. Silvio
Chiorini, John A.
author_facet Weller, Melodie L.
Amornphimoltham, Panomwat
Schmidt, Michael
Wilson, Paul A.
Gutkind, J. Silvio
Chiorini, John A.
author_sort Weller, Melodie L.
collection PubMed
description A critical step in gene therapy is the efficient transfer of genes in a cell-type and tissue specific manner. To better understand the mechanism of AAV6 transduction we used CGA combined with pathway visualization software to identify a positive correlation between AAV6 transduction and EGFR expression. Subsequent experiments suggest EGFR is necessary for vector internalization and likely functions as a co-receptor for this virus.
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spelling pubmed-28857162010-12-01 Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6 Weller, Melodie L. Amornphimoltham, Panomwat Schmidt, Michael Wilson, Paul A. Gutkind, J. Silvio Chiorini, John A. Nat Med Article A critical step in gene therapy is the efficient transfer of genes in a cell-type and tissue specific manner. To better understand the mechanism of AAV6 transduction we used CGA combined with pathway visualization software to identify a positive correlation between AAV6 transduction and EGFR expression. Subsequent experiments suggest EGFR is necessary for vector internalization and likely functions as a co-receptor for this virus. 2010-05-09 2010-06 /pmc/articles/PMC2885716/ /pubmed/20473307 http://dx.doi.org/10.1038/nm.2145 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Weller, Melodie L.
Amornphimoltham, Panomwat
Schmidt, Michael
Wilson, Paul A.
Gutkind, J. Silvio
Chiorini, John A.
Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
title Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
title_full Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
title_fullStr Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
title_full_unstemmed Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
title_short Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
title_sort epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885716/
https://www.ncbi.nlm.nih.gov/pubmed/20473307
http://dx.doi.org/10.1038/nm.2145
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