Kidney Injury Molecule-1 Outperforms Traditional Biomarkers of Kidney Injury in Multi-site Preclinical Biomarker Qualification Studies

Kidney toxicity accounts for a significant percentage of morbidity and drug candidate failure. Serum creatinine (SCr) and blood urea nitrogen (BUN) have been used to monitor kidney dysfunction for over a century but these markers are insensitive and non-specific. In multi-site preclinical rat toxico...

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Detalles Bibliográficos
Autores principales: Vaidya, Vishal S., Ozer, Josef S., Frank, Dieterle, Collings, Fitz B., Ramirez, Victoria, Troth, Sean, Muniappa, Nagaraja, Thudium, Douglas, Gerhold, David, Holder, Daniel J., Bobadilla, Norma A., Marrer, Estelle, Perentes, Elias, Cordier, André, Vonderscher, Jacky, Maurer, Gérard, Goering, Peter L., Sistare, Frank D., Bonventre, Joseph V.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885849/
https://www.ncbi.nlm.nih.gov/pubmed/20458318
http://dx.doi.org/10.1038/nbt.1623

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