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Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines
PURPOSE: Oxaliplatin effect in the treatment of colorectal cancer is improved upon combination with thymidylate synthase (TS) inhibitors. Pemetrexed is polyglutamated by the folylpolyglutamate synthase (FPGS) and blocks folate metabolism and DNA synthesis by inhibiting TS, dihydrofolate reductase (D...
Autores principales: | Nannizzi, Sara, Veal, Gareth J., Giovannetti, Elisa, Mey, Valentina, Ricciardi, Simona, Ottley, Christopher J., Del Tacca, Mario, Danesi, Romano |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886085/ https://www.ncbi.nlm.nih.gov/pubmed/20020129 http://dx.doi.org/10.1007/s00280-009-1195-2 |
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