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Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines

PURPOSE: Oxaliplatin effect in the treatment of colorectal cancer is improved upon combination with thymidylate synthase (TS) inhibitors. Pemetrexed is polyglutamated by the folylpolyglutamate synthase (FPGS) and blocks folate metabolism and DNA synthesis by inhibiting TS, dihydrofolate reductase (D...

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Detalles Bibliográficos
Autores principales:	Nannizzi, Sara, Veal, Gareth J., Giovannetti, Elisa, Mey, Valentina, Ricciardi, Simona, Ottley, Christopher J., Del Tacca, Mario, Danesi, Romano
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886085/ https://www.ncbi.nlm.nih.gov/pubmed/20020129 http://dx.doi.org/10.1007/s00280-009-1195-2

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