HIV-1 Neutralization Profile and Plant-Based Recombinant Expression of Actinohivin, an Env Glycan-Specific Lectin Devoid of T-Cell Mitogenic Activity

The development of a topical microbicide blocking the sexual transmission of HIV-1 is urgently needed to control the global HIV/AIDS pandemic. The actinomycete-derived lectin actinohivin (AH) is highly specific to a cluster of high-mannose-type glycans uniquely found on the viral envelope (Env). Her...

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Detalles Bibliográficos
Autores principales: Matoba, Nobuyuki, Husk, Adam S., Barnett, Brian W., Pickel, Michelle M., Arntzen, Charles J., Montefiori, David C., Takahashi, Atsushi, Tanno, Kazunobu, Omura, Satoshi, Cao, Huyen, Mooney, Jason P., Hanson, Carl V., Tanaka, Haruo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886112/
https://www.ncbi.nlm.nih.gov/pubmed/20559567
http://dx.doi.org/10.1371/journal.pone.0011143

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