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The Pathology of EMT in Mouse Mammary Tumorigenesis
Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recent...
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| Formato: | Texto |
| Lenguaje: | English |
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Springer US
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886116/ https://www.ncbi.nlm.nih.gov/pubmed/20521088 http://dx.doi.org/10.1007/s10911-010-9184-y |
| _version_ | 1782182445525762048 |
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| author | Cardiff, Robert Darrell |
| author_facet | Cardiff, Robert Darrell |
| author_sort | Cardiff, Robert Darrell |
| collection | PubMed |
| description | Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer. |
| format | Text |
| id | pubmed-2886116 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | Springer US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28861162010-07-21 The Pathology of EMT in Mouse Mammary Tumorigenesis Cardiff, Robert Darrell J Mammary Gland Biol Neoplasia Article Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer. Springer US 2010-06-04 2010 /pmc/articles/PMC2886116/ /pubmed/20521088 http://dx.doi.org/10.1007/s10911-010-9184-y Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
| spellingShingle | Article Cardiff, Robert Darrell The Pathology of EMT in Mouse Mammary Tumorigenesis |
| title | The Pathology of EMT in Mouse Mammary Tumorigenesis |
| title_full | The Pathology of EMT in Mouse Mammary Tumorigenesis |
| title_fullStr | The Pathology of EMT in Mouse Mammary Tumorigenesis |
| title_full_unstemmed | The Pathology of EMT in Mouse Mammary Tumorigenesis |
| title_short | The Pathology of EMT in Mouse Mammary Tumorigenesis |
| title_sort | pathology of emt in mouse mammary tumorigenesis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886116/ https://www.ncbi.nlm.nih.gov/pubmed/20521088 http://dx.doi.org/10.1007/s10911-010-9184-y |
| work_keys_str_mv | AT cardiffrobertdarrell thepathologyofemtinmousemammarytumorigenesis AT cardiffrobertdarrell pathologyofemtinmousemammarytumorigenesis |