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Effectiveness of rotavirus vaccination against childhood diarrhoea in El Salvador: case-control study

Objective To evaluate the effectiveness of a monovalent rotavirus vaccine against severe rotavirus disease and to assess its impact on diarrhoea in children aged less than 2 years after national introduction in El Salvador, a low-middle income country in Central America. Design Matched case-control...

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Autores principales: de Palma, Orbelina, Cruz, Lilian, Ramos, Hector, de Baires, Amada, Villatoro, Nora, Pastor, Desiree, de Oliveira, Lucia Helena, Kerin, Tara, Bowen, Michael, Gentsch, Jon, Esposito, Douglas H, Parashar, Umesh, Tate, Jacqueline, Patel, Manish
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886195/
https://www.ncbi.nlm.nih.gov/pubmed/20551120
http://dx.doi.org/10.1136/bmj.c2825
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author de Palma, Orbelina
Cruz, Lilian
Ramos, Hector
de Baires, Amada
Villatoro, Nora
Pastor, Desiree
de Oliveira, Lucia Helena
Kerin, Tara
Bowen, Michael
Gentsch, Jon
Esposito, Douglas H
Parashar, Umesh
Tate, Jacqueline
Patel, Manish
author_facet de Palma, Orbelina
Cruz, Lilian
Ramos, Hector
de Baires, Amada
Villatoro, Nora
Pastor, Desiree
de Oliveira, Lucia Helena
Kerin, Tara
Bowen, Michael
Gentsch, Jon
Esposito, Douglas H
Parashar, Umesh
Tate, Jacqueline
Patel, Manish
author_sort de Palma, Orbelina
collection PubMed
description Objective To evaluate the effectiveness of a monovalent rotavirus vaccine against severe rotavirus disease and to assess its impact on diarrhoea in children aged less than 2 years after national introduction in El Salvador, a low-middle income country in Central America. Design Matched case-control study. Setting Seven hospitals in cities across El Salvador, January 2007 to June 2009. Participants 323 children aged less than 2 years admitted with laboratory confirmed rotavirus diarrhoea and 969 healthy controls matched for age and neighbourhood. Main outcome measure Effectiveness of rotavirus vaccination ((1–adjusted odds ratio of vaccination)×100) against rotavirus diarrhoea requiring hospital admission. Results Cases and controls were similar for breast feeding, premature birth, maternal education, and socioeconomic variables. G1P[8] strains were identified in 92% of rotavirus cases. Effectiveness of two doses of vaccination against diarrhoea requiring hospital admission was 76% (95% confidence interval 64% to 84%). Protection was significantly lower (P=0.046) among children aged 12 months or more (59%, 27% to 77%) compared with children aged 6-11 months (83%, 68% to 91%). One dose of vaccine was 51% (26% to 67%) effective. At the sentinel hospitals, all admissions for diarrhoea among children under 5 declined by 40% in 2008 and by 51% in 2009 from the prevaccine year 2006. Conclusions A monovalent rotavirus vaccine was highly effective against admissions for rotavirus diarrhoea in children aged less than 2 years in El Salvador and substantially reduced the number of such admissions in this low-middle income setting. The impact on disease epidemiology after vaccination, particularly among older children, warrants future attention.
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spelling pubmed-28861952010-06-16 Effectiveness of rotavirus vaccination against childhood diarrhoea in El Salvador: case-control study de Palma, Orbelina Cruz, Lilian Ramos, Hector de Baires, Amada Villatoro, Nora Pastor, Desiree de Oliveira, Lucia Helena Kerin, Tara Bowen, Michael Gentsch, Jon Esposito, Douglas H Parashar, Umesh Tate, Jacqueline Patel, Manish BMJ Research Objective To evaluate the effectiveness of a monovalent rotavirus vaccine against severe rotavirus disease and to assess its impact on diarrhoea in children aged less than 2 years after national introduction in El Salvador, a low-middle income country in Central America. Design Matched case-control study. Setting Seven hospitals in cities across El Salvador, January 2007 to June 2009. Participants 323 children aged less than 2 years admitted with laboratory confirmed rotavirus diarrhoea and 969 healthy controls matched for age and neighbourhood. Main outcome measure Effectiveness of rotavirus vaccination ((1–adjusted odds ratio of vaccination)×100) against rotavirus diarrhoea requiring hospital admission. Results Cases and controls were similar for breast feeding, premature birth, maternal education, and socioeconomic variables. G1P[8] strains were identified in 92% of rotavirus cases. Effectiveness of two doses of vaccination against diarrhoea requiring hospital admission was 76% (95% confidence interval 64% to 84%). Protection was significantly lower (P=0.046) among children aged 12 months or more (59%, 27% to 77%) compared with children aged 6-11 months (83%, 68% to 91%). One dose of vaccine was 51% (26% to 67%) effective. At the sentinel hospitals, all admissions for diarrhoea among children under 5 declined by 40% in 2008 and by 51% in 2009 from the prevaccine year 2006. Conclusions A monovalent rotavirus vaccine was highly effective against admissions for rotavirus diarrhoea in children aged less than 2 years in El Salvador and substantially reduced the number of such admissions in this low-middle income setting. The impact on disease epidemiology after vaccination, particularly among older children, warrants future attention. BMJ Publishing Group Ltd. 2010-06-15 /pmc/articles/PMC2886195/ /pubmed/20551120 http://dx.doi.org/10.1136/bmj.c2825 Text en © de Palma et al 2010 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Research
de Palma, Orbelina
Cruz, Lilian
Ramos, Hector
de Baires, Amada
Villatoro, Nora
Pastor, Desiree
de Oliveira, Lucia Helena
Kerin, Tara
Bowen, Michael
Gentsch, Jon
Esposito, Douglas H
Parashar, Umesh
Tate, Jacqueline
Patel, Manish
Effectiveness of rotavirus vaccination against childhood diarrhoea in El Salvador: case-control study
title Effectiveness of rotavirus vaccination against childhood diarrhoea in El Salvador: case-control study
title_full Effectiveness of rotavirus vaccination against childhood diarrhoea in El Salvador: case-control study
title_fullStr Effectiveness of rotavirus vaccination against childhood diarrhoea in El Salvador: case-control study
title_full_unstemmed Effectiveness of rotavirus vaccination against childhood diarrhoea in El Salvador: case-control study
title_short Effectiveness of rotavirus vaccination against childhood diarrhoea in El Salvador: case-control study
title_sort effectiveness of rotavirus vaccination against childhood diarrhoea in el salvador: case-control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886195/
https://www.ncbi.nlm.nih.gov/pubmed/20551120
http://dx.doi.org/10.1136/bmj.c2825
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