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Topiramate-induced angle closure with acute myopia, macular striae

Topiramate is a sulfamate-substituted monosaccharide used in the treatment of seizures, and prophylaxis of migraine. A number of ocular side-effects have been described with use of topiramate, like bilateral angle closure, acute myopia and macular striae. Ultrasound biomicroscopy (UBM) clinches the...

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Detalles Bibliográficos
Autores principales: Natesh, S., Rajashekhara, S. K., Rao, A. S. D., Shetty, B.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886232/
https://www.ncbi.nlm.nih.gov/pubmed/20606870
http://dx.doi.org/10.4103/0974-620X.60018
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author Natesh, S.
Rajashekhara, S. K.
Rao, A. S. D.
Shetty, B.
author_facet Natesh, S.
Rajashekhara, S. K.
Rao, A. S. D.
Shetty, B.
author_sort Natesh, S.
collection PubMed
description Topiramate is a sulfamate-substituted monosaccharide used in the treatment of seizures, and prophylaxis of migraine. A number of ocular side-effects have been described with use of topiramate, like bilateral angle closure, acute myopia and macular striae. Ultrasound biomicroscopy (UBM) clinches the diagnosis after ruling out other causes of shallow anterior chamber. Previous studies have not demonstrated internal limiting membrane folds presenting as macular striae. We report a case of topiramate-induced acute myopia with angle closure and macular striae in a young adult. This is the first report wherein striae formation after low doses of topiramate and their resolution have been documented by Optical Coherence Tomography (OCT).
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spelling pubmed-28862322010-07-02 Topiramate-induced angle closure with acute myopia, macular striae Natesh, S. Rajashekhara, S. K. Rao, A. S. D. Shetty, B. Oman J Ophthalmol Case Report Topiramate is a sulfamate-substituted monosaccharide used in the treatment of seizures, and prophylaxis of migraine. A number of ocular side-effects have been described with use of topiramate, like bilateral angle closure, acute myopia and macular striae. Ultrasound biomicroscopy (UBM) clinches the diagnosis after ruling out other causes of shallow anterior chamber. Previous studies have not demonstrated internal limiting membrane folds presenting as macular striae. We report a case of topiramate-induced acute myopia with angle closure and macular striae in a young adult. This is the first report wherein striae formation after low doses of topiramate and their resolution have been documented by Optical Coherence Tomography (OCT). Medknow Publications 2010 /pmc/articles/PMC2886232/ /pubmed/20606870 http://dx.doi.org/10.4103/0974-620X.60018 Text en © Oman Journal of Ophthalmology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Natesh, S.
Rajashekhara, S. K.
Rao, A. S. D.
Shetty, B.
Topiramate-induced angle closure with acute myopia, macular striae
title Topiramate-induced angle closure with acute myopia, macular striae
title_full Topiramate-induced angle closure with acute myopia, macular striae
title_fullStr Topiramate-induced angle closure with acute myopia, macular striae
title_full_unstemmed Topiramate-induced angle closure with acute myopia, macular striae
title_short Topiramate-induced angle closure with acute myopia, macular striae
title_sort topiramate-induced angle closure with acute myopia, macular striae
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886232/
https://www.ncbi.nlm.nih.gov/pubmed/20606870
http://dx.doi.org/10.4103/0974-620X.60018
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