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The Neurological Safety of Epidural Pamidronate in Rats

BACKGROUND: Pamidronate is a potent inhibitor of osteoclast-mediated bone resorption. Recently, the drug has been known to relieve bone pain. We hypothesized that direct epidural administration of pamidronate could have various advantages over oral administration with respect to dosage, side effects...

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Autores principales: Lee, Pyung Bok, Kim, Yong Chul, Lee, Chul Joong, Shin, Hye Young, Lee, Seung Yun, Park, Jong Cook, Choi, Yun Suk, Kim, Chong Soo, Park, Sang Hyun
Formato: Texto
Lenguaje:English
Publicado: The Korean Pain Society 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886240/
https://www.ncbi.nlm.nih.gov/pubmed/20556213
http://dx.doi.org/10.3344/kjp.2010.23.2.116
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author Lee, Pyung Bok
Kim, Yong Chul
Lee, Chul Joong
Shin, Hye Young
Lee, Seung Yun
Park, Jong Cook
Choi, Yun Suk
Kim, Chong Soo
Park, Sang Hyun
author_facet Lee, Pyung Bok
Kim, Yong Chul
Lee, Chul Joong
Shin, Hye Young
Lee, Seung Yun
Park, Jong Cook
Choi, Yun Suk
Kim, Chong Soo
Park, Sang Hyun
author_sort Lee, Pyung Bok
collection PubMed
description BACKGROUND: Pamidronate is a potent inhibitor of osteoclast-mediated bone resorption. Recently, the drug has been known to relieve bone pain. We hypothesized that direct epidural administration of pamidronate could have various advantages over oral administration with respect to dosage, side effects, and efficacy. Therefore, we evaluated the neuronal safety of epidurally-administered pamidronate. METHODS: Twenty-seven rats weighing 250-350 g were equally divided into 3 groups. Each group received an epidural administration with either 0.3 ml (3.75 mg) of pamidronate (group P), 0.3 ml of 40% alcohol (group A), or 0.3 ml of normal saline (group N). A Pinch-toe test, motor function evaluation, and histopathologic examination of the spinal cord to detect conditions such as chromatolysis, meningeal inflammation, and neuritis, were performed on the 2nd, 7th, and 21st day following administration of each drug. RESULTS: All rats in group A showed an abnormal response to the pinch-toe test and decreased motor function during the entire evaluation period. Abnormal histopathologic findings, including neuritis and meningeal inflammation were observed only in group A rats. Rats in group P, with the exception of 1, and group N showed no significant sensory/motor dysfunction over a 3-week observation period. No histopathologic changes were observed in groups P and N. CONCLUSIONS: Direct epidural injection of pamidronate (about 12.5 mg/kg) showed no neurotoxic evidence in terms of sensory/motor function evaluation and histopathologic examination.
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spelling pubmed-28862402010-06-16 The Neurological Safety of Epidural Pamidronate in Rats Lee, Pyung Bok Kim, Yong Chul Lee, Chul Joong Shin, Hye Young Lee, Seung Yun Park, Jong Cook Choi, Yun Suk Kim, Chong Soo Park, Sang Hyun Korean J Pain Original Article BACKGROUND: Pamidronate is a potent inhibitor of osteoclast-mediated bone resorption. Recently, the drug has been known to relieve bone pain. We hypothesized that direct epidural administration of pamidronate could have various advantages over oral administration with respect to dosage, side effects, and efficacy. Therefore, we evaluated the neuronal safety of epidurally-administered pamidronate. METHODS: Twenty-seven rats weighing 250-350 g were equally divided into 3 groups. Each group received an epidural administration with either 0.3 ml (3.75 mg) of pamidronate (group P), 0.3 ml of 40% alcohol (group A), or 0.3 ml of normal saline (group N). A Pinch-toe test, motor function evaluation, and histopathologic examination of the spinal cord to detect conditions such as chromatolysis, meningeal inflammation, and neuritis, were performed on the 2nd, 7th, and 21st day following administration of each drug. RESULTS: All rats in group A showed an abnormal response to the pinch-toe test and decreased motor function during the entire evaluation period. Abnormal histopathologic findings, including neuritis and meningeal inflammation were observed only in group A rats. Rats in group P, with the exception of 1, and group N showed no significant sensory/motor dysfunction over a 3-week observation period. No histopathologic changes were observed in groups P and N. CONCLUSIONS: Direct epidural injection of pamidronate (about 12.5 mg/kg) showed no neurotoxic evidence in terms of sensory/motor function evaluation and histopathologic examination. The Korean Pain Society 2010-06 2010-05-31 /pmc/articles/PMC2886240/ /pubmed/20556213 http://dx.doi.org/10.3344/kjp.2010.23.2.116 Text en Copyright © The Korean Pain Society, 2010 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Pyung Bok
Kim, Yong Chul
Lee, Chul Joong
Shin, Hye Young
Lee, Seung Yun
Park, Jong Cook
Choi, Yun Suk
Kim, Chong Soo
Park, Sang Hyun
The Neurological Safety of Epidural Pamidronate in Rats
title The Neurological Safety of Epidural Pamidronate in Rats
title_full The Neurological Safety of Epidural Pamidronate in Rats
title_fullStr The Neurological Safety of Epidural Pamidronate in Rats
title_full_unstemmed The Neurological Safety of Epidural Pamidronate in Rats
title_short The Neurological Safety of Epidural Pamidronate in Rats
title_sort neurological safety of epidural pamidronate in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886240/
https://www.ncbi.nlm.nih.gov/pubmed/20556213
http://dx.doi.org/10.3344/kjp.2010.23.2.116
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