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Targeting cancers in the gastrointestinal tract: role of capecitabine

Capecitabine is currently the only novel, orally home-administered fluorouracil prodrug. It offers patients more freedom from hospital visits and less inconvenience and complications associated with infusion devices. The drug has been extensively studied in large clinical trials in many solid tumors...

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Detalles Bibliográficos
Autor principal: Saif, Muhammad Wasif
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886333/
https://www.ncbi.nlm.nih.gov/pubmed/20616892
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author Saif, Muhammad Wasif
author_facet Saif, Muhammad Wasif
author_sort Saif, Muhammad Wasif
collection PubMed
description Capecitabine is currently the only novel, orally home-administered fluorouracil prodrug. It offers patients more freedom from hospital visits and less inconvenience and complications associated with infusion devices. The drug has been extensively studied in large clinical trials in many solid tumors, including breast cancer, colorectal cancer, gastric cancer, and many others. Furthermore, the drug compares favorably with fluorouracil in patients with such cancers, with a safe toxicity profile, consisting mainly of gastrointestinal and dermatologic adverse effects. Whereas gastrointestinal events and hand-foot syndrome occur often with capecitabine, the tolerability profile is comparatively favorable. Prompt recognition of severe adverse effects is the key to successful management of capecitabine. Ongoing and future clinical trials will continue to examine, and likely expand, the role of capecitabine as a single agent and/or in combination with other anticancer agents for the treatment of gastrointestinal as well as other solid tumors, both in the advanced palliative and adjuvant settings. The author summarizes the current data on the role of capecitabine in the management of gastrointestinal cancers.
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spelling pubmed-28863332010-07-08 Targeting cancers in the gastrointestinal tract: role of capecitabine Saif, Muhammad Wasif Onco Targets Ther Review Capecitabine is currently the only novel, orally home-administered fluorouracil prodrug. It offers patients more freedom from hospital visits and less inconvenience and complications associated with infusion devices. The drug has been extensively studied in large clinical trials in many solid tumors, including breast cancer, colorectal cancer, gastric cancer, and many others. Furthermore, the drug compares favorably with fluorouracil in patients with such cancers, with a safe toxicity profile, consisting mainly of gastrointestinal and dermatologic adverse effects. Whereas gastrointestinal events and hand-foot syndrome occur often with capecitabine, the tolerability profile is comparatively favorable. Prompt recognition of severe adverse effects is the key to successful management of capecitabine. Ongoing and future clinical trials will continue to examine, and likely expand, the role of capecitabine as a single agent and/or in combination with other anticancer agents for the treatment of gastrointestinal as well as other solid tumors, both in the advanced palliative and adjuvant settings. The author summarizes the current data on the role of capecitabine in the management of gastrointestinal cancers. Dove Medical Press 2009-02-18 /pmc/articles/PMC2886333/ /pubmed/20616892 Text en © 2009 Saif, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Saif, Muhammad Wasif
Targeting cancers in the gastrointestinal tract: role of capecitabine
title Targeting cancers in the gastrointestinal tract: role of capecitabine
title_full Targeting cancers in the gastrointestinal tract: role of capecitabine
title_fullStr Targeting cancers in the gastrointestinal tract: role of capecitabine
title_full_unstemmed Targeting cancers in the gastrointestinal tract: role of capecitabine
title_short Targeting cancers in the gastrointestinal tract: role of capecitabine
title_sort targeting cancers in the gastrointestinal tract: role of capecitabine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886333/
https://www.ncbi.nlm.nih.gov/pubmed/20616892
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