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The Drosophila neural lineages: a model system to study brain development and circuitry

In Drosophila, neurons of the central nervous system are grouped into units called lineages. Each lineage contains cells derived from a single neuroblast. Due to its clonal nature, the Drosophila brain is a valuable model system to study neuron development and circuit formation. To better understand...

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Detalles Bibliográficos
Autores principales: Spindler, Shana R., Hartenstein, Volker
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886914/
https://www.ncbi.nlm.nih.gov/pubmed/20306203
http://dx.doi.org/10.1007/s00427-010-0323-7
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author Spindler, Shana R.
Hartenstein, Volker
author_facet Spindler, Shana R.
Hartenstein, Volker
author_sort Spindler, Shana R.
collection PubMed
description In Drosophila, neurons of the central nervous system are grouped into units called lineages. Each lineage contains cells derived from a single neuroblast. Due to its clonal nature, the Drosophila brain is a valuable model system to study neuron development and circuit formation. To better understand the mechanisms underlying brain development, genetic manipulation tools can be utilized within lineages to visualize, knock down, or over-express proteins. Here, we will introduce the formation and development of lineages, discuss how one can utilize this model system, offer a comprehensive list of known lineages and their respective markers, and then briefly review studies that have utilized Drosophila neural lineages with a look at how this model system can benefit future endeavors.
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spelling pubmed-28869142010-07-21 The Drosophila neural lineages: a model system to study brain development and circuitry Spindler, Shana R. Hartenstein, Volker Dev Genes Evol Review In Drosophila, neurons of the central nervous system are grouped into units called lineages. Each lineage contains cells derived from a single neuroblast. Due to its clonal nature, the Drosophila brain is a valuable model system to study neuron development and circuit formation. To better understand the mechanisms underlying brain development, genetic manipulation tools can be utilized within lineages to visualize, knock down, or over-express proteins. Here, we will introduce the formation and development of lineages, discuss how one can utilize this model system, offer a comprehensive list of known lineages and their respective markers, and then briefly review studies that have utilized Drosophila neural lineages with a look at how this model system can benefit future endeavors. Springer-Verlag 2010-03-20 2010 /pmc/articles/PMC2886914/ /pubmed/20306203 http://dx.doi.org/10.1007/s00427-010-0323-7 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review
Spindler, Shana R.
Hartenstein, Volker
The Drosophila neural lineages: a model system to study brain development and circuitry
title The Drosophila neural lineages: a model system to study brain development and circuitry
title_full The Drosophila neural lineages: a model system to study brain development and circuitry
title_fullStr The Drosophila neural lineages: a model system to study brain development and circuitry
title_full_unstemmed The Drosophila neural lineages: a model system to study brain development and circuitry
title_short The Drosophila neural lineages: a model system to study brain development and circuitry
title_sort drosophila neural lineages: a model system to study brain development and circuitry
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886914/
https://www.ncbi.nlm.nih.gov/pubmed/20306203
http://dx.doi.org/10.1007/s00427-010-0323-7
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