Cargando…
Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications
Seasonal and pandemic influenza are frequently complicated by bacterial infections, causing additional hospitalization and mortality. Secondary bacterial respiratory infection can be subdivided into combined viral/bacterial pneumonia and post-influenza pneumonia, which differ in their pathogenesis....
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887122/ https://www.ncbi.nlm.nih.gov/pubmed/20459593 http://dx.doi.org/10.1186/cc8893 |
_version_ | 1782182508399427584 |
---|---|
author | van der Sluijs, Koenraad F van der Poll, Tom Lutter, René Juffermans, Nicole P Schultz, Marcus J |
author_facet | van der Sluijs, Koenraad F van der Poll, Tom Lutter, René Juffermans, Nicole P Schultz, Marcus J |
author_sort | van der Sluijs, Koenraad F |
collection | PubMed |
description | Seasonal and pandemic influenza are frequently complicated by bacterial infections, causing additional hospitalization and mortality. Secondary bacterial respiratory infection can be subdivided into combined viral/bacterial pneumonia and post-influenza pneumonia, which differ in their pathogenesis. During combined viral/bacterial infection, the virus, the bacterium and the host interact with each other. Post-influenza pneumonia may, at least in part, be due to resolution of inflammation caused by the primary viral infection. These mechanisms restore tissue homeostasis but greatly impair the host response against unrelated bacterial pathogens. In this review we summarize the underlying mechanisms leading to combined viral/bacterial infection or post-influenza pneumonia and highlight important considerations for effective treatment of bacterial pneumonia during and shortly after influenza. |
format | Text |
id | pubmed-2887122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28871222011-04-19 Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications van der Sluijs, Koenraad F van der Poll, Tom Lutter, René Juffermans, Nicole P Schultz, Marcus J Crit Care Review Seasonal and pandemic influenza are frequently complicated by bacterial infections, causing additional hospitalization and mortality. Secondary bacterial respiratory infection can be subdivided into combined viral/bacterial pneumonia and post-influenza pneumonia, which differ in their pathogenesis. During combined viral/bacterial infection, the virus, the bacterium and the host interact with each other. Post-influenza pneumonia may, at least in part, be due to resolution of inflammation caused by the primary viral infection. These mechanisms restore tissue homeostasis but greatly impair the host response against unrelated bacterial pathogens. In this review we summarize the underlying mechanisms leading to combined viral/bacterial infection or post-influenza pneumonia and highlight important considerations for effective treatment of bacterial pneumonia during and shortly after influenza. BioMed Central 2010 2010-04-19 /pmc/articles/PMC2887122/ /pubmed/20459593 http://dx.doi.org/10.1186/cc8893 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Review van der Sluijs, Koenraad F van der Poll, Tom Lutter, René Juffermans, Nicole P Schultz, Marcus J Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications |
title | Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications |
title_full | Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications |
title_fullStr | Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications |
title_full_unstemmed | Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications |
title_short | Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications |
title_sort | bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887122/ https://www.ncbi.nlm.nih.gov/pubmed/20459593 http://dx.doi.org/10.1186/cc8893 |
work_keys_str_mv | AT vandersluijskoenraadf benchtobedsidereviewbacterialpneumoniawithinfluenzapathogenesisandclinicalimplications AT vanderpolltom benchtobedsidereviewbacterialpneumoniawithinfluenzapathogenesisandclinicalimplications AT lutterrene benchtobedsidereviewbacterialpneumoniawithinfluenzapathogenesisandclinicalimplications AT juffermansnicolep benchtobedsidereviewbacterialpneumoniawithinfluenzapathogenesisandclinicalimplications AT schultzmarcusj benchtobedsidereviewbacterialpneumoniawithinfluenzapathogenesisandclinicalimplications |