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Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure

INTRODUCTION: The objectives were to characterize alveolar fluid clearance (AFC) in pigs with normal lungs and to analyze the effect of immediate application of positive end-expiratory pressure (PEEP). METHODS: Animals (n = 25) were mechanically ventilated and divided into four groups: small edema (...

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Autores principales: García-Delgado, Manuel, Touma-Fernández, Ángel, Chamorro-Marín, Virginia, Ruiz-Aguilar, Antonio, Aguilar-Alonso, Eduardo, Fernández-Mondéjar, Enrique
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887143/
https://www.ncbi.nlm.nih.gov/pubmed/20233408
http://dx.doi.org/10.1186/cc8914
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author García-Delgado, Manuel
Touma-Fernández, Ángel
Chamorro-Marín, Virginia
Ruiz-Aguilar, Antonio
Aguilar-Alonso, Eduardo
Fernández-Mondéjar, Enrique
author_facet García-Delgado, Manuel
Touma-Fernández, Ángel
Chamorro-Marín, Virginia
Ruiz-Aguilar, Antonio
Aguilar-Alonso, Eduardo
Fernández-Mondéjar, Enrique
author_sort García-Delgado, Manuel
collection PubMed
description INTRODUCTION: The objectives were to characterize alveolar fluid clearance (AFC) in pigs with normal lungs and to analyze the effect of immediate application of positive end-expiratory pressure (PEEP). METHODS: Animals (n = 25) were mechanically ventilated and divided into four groups: small edema (SE) group, producing pulmonary edema (PE) by intratracheal instillation of 4 ml/kg of saline solution; small edema with PEEP (SE + PEEP) group, same as previous but applying PEEP of 10 cmH(2)O; large edema (LE) group, producing PE by instillation of 10 ml/kg of saline solution; and large edema with PEEP (LE + PEEP) group, same as LE group but applying PEEP of 10 cmH(2)O. AFC was estimated from differences in extravascular lung water values obtained by transpulmonary thermodilution method. RESULTS: At one hour, AFC was 19.4% in SE group and 18.0% in LE group. In the SE + PEEP group, the AFC rate was higher at one hour than at subsequent time points and higher than in the SE group (45.4% vs. 19.4% at one hour, P < 0.05). The AFC rate was also significantly higher in the LE + PEEP than in the LE group at three hours and four hours. CONCLUSIONS: In this pig model, the AFC rate is around 20% at one hour and around 50% at four hours, regardless of the amount of edema, and is increased by the application of PEEP.
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spelling pubmed-28871432010-06-18 Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure García-Delgado, Manuel Touma-Fernández, Ángel Chamorro-Marín, Virginia Ruiz-Aguilar, Antonio Aguilar-Alonso, Eduardo Fernández-Mondéjar, Enrique Crit Care Research INTRODUCTION: The objectives were to characterize alveolar fluid clearance (AFC) in pigs with normal lungs and to analyze the effect of immediate application of positive end-expiratory pressure (PEEP). METHODS: Animals (n = 25) were mechanically ventilated and divided into four groups: small edema (SE) group, producing pulmonary edema (PE) by intratracheal instillation of 4 ml/kg of saline solution; small edema with PEEP (SE + PEEP) group, same as previous but applying PEEP of 10 cmH(2)O; large edema (LE) group, producing PE by instillation of 10 ml/kg of saline solution; and large edema with PEEP (LE + PEEP) group, same as LE group but applying PEEP of 10 cmH(2)O. AFC was estimated from differences in extravascular lung water values obtained by transpulmonary thermodilution method. RESULTS: At one hour, AFC was 19.4% in SE group and 18.0% in LE group. In the SE + PEEP group, the AFC rate was higher at one hour than at subsequent time points and higher than in the SE group (45.4% vs. 19.4% at one hour, P < 0.05). The AFC rate was also significantly higher in the LE + PEEP than in the LE group at three hours and four hours. CONCLUSIONS: In this pig model, the AFC rate is around 20% at one hour and around 50% at four hours, regardless of the amount of edema, and is increased by the application of PEEP. BioMed Central 2010 2010-03-16 /pmc/articles/PMC2887143/ /pubmed/20233408 http://dx.doi.org/10.1186/cc8914 Text en Copyright ©2010 García-Delgado et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
García-Delgado, Manuel
Touma-Fernández, Ángel
Chamorro-Marín, Virginia
Ruiz-Aguilar, Antonio
Aguilar-Alonso, Eduardo
Fernández-Mondéjar, Enrique
Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure
title Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure
title_full Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure
title_fullStr Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure
title_full_unstemmed Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure
title_short Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure
title_sort alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887143/
https://www.ncbi.nlm.nih.gov/pubmed/20233408
http://dx.doi.org/10.1186/cc8914
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