Mechanical ventilation with high tidal volume induces inflammation in patients without lung disease

INTRODUCTION: Mechanical ventilation (MV) with high tidal volumes may induce or aggravate lung injury in critical ill patients. We compared the effects of a protective versus a conventional ventilatory strategy, on systemic and lung production of tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in patients without lung disease. METHODS: Patients without lung disease and submitted to mechanical ventilation admitted to one trauma and one general adult intensive care unit of two different university hospitals were enrolled in a prospective randomized-control study. Patients were randomized to receive MV either with tidal volume (V(T)) of 10 to 12 ml/kg predicted body weight (high V(T )group) (n = 10) or with V(T )of 5 to 7 ml/kg predicted body weight (low V(T )group) (n = 10) with an oxygen inspiratory fraction (FIO(2)) enough to keep arterial oxygen saturation >90% with positive end-expiratory pressure (PEEP) of 5 cmH(2)O during 12 hours after admission to the study. TNF-α and IL-8 concentrations were measured in the serum and in the bronchoalveolar lavage fluid (BALF) at admission and after 12 hours of study observation time. RESULTS: Twenty patients were enrolled and analyzed. At admission or after 12 hours there were no differences in serum TNF-α and IL-8 between the two groups. While initial analysis did not reveal significant differences, standardization against urea of logarithmic transformed data revealed that TNF-α and IL-8 levels in bronchoalveolar lavage (BAL) fluid were stable in the low V(T )group but increased in the high V(T )group (P = 0.04 and P = 0.03). After 12 hours, BALF TNF-α (P = 0.03) and BALF IL-8 concentrations (P = 0.03) were higher in the high V(T )group than in the low V(T )group. CONCLUSIONS: The use of lower tidal volumes may limit pulmonary inflammation in mechanically ventilated patients even without lung injury. TRIAL REGISTRATION: Clinical Trial registration: NCT00935896