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Febrile neutropenia in French emergency departments: results of a prospective multicentre survey
INTRODUCTION: Febrile neutropenia (FN) is common in cancer patients receiving myelotoxic therapy. The procedures to treat FN are well established in oncology, but it is unclear whether management is adequate in the emergency department (ED). METHODS: This prospective, multicentre, observational stud...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887190/ https://www.ncbi.nlm.nih.gov/pubmed/20403164 http://dx.doi.org/10.1186/cc8972 |
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author | André, Stéphanie Taboulet, Pierre Elie, Caroline Milpied, Noël Nahon, Michel Kierzek, Gérald Billemont, Mariève Perruche, Franck Charpentier, Sandrine Clément, Hélène Pourriat, Jean-Louis Claessens, Yann-Erick |
author_facet | André, Stéphanie Taboulet, Pierre Elie, Caroline Milpied, Noël Nahon, Michel Kierzek, Gérald Billemont, Mariève Perruche, Franck Charpentier, Sandrine Clément, Hélène Pourriat, Jean-Louis Claessens, Yann-Erick |
author_sort | André, Stéphanie |
collection | PubMed |
description | INTRODUCTION: Febrile neutropenia (FN) is common in cancer patients receiving myelotoxic therapy. The procedures to treat FN are well established in oncology, but it is unclear whether management is adequate in the emergency department (ED). METHODS: This prospective, multicentre, observational study was carried out in 47 French EDs for 6 months. Patients were adults presenting at the ED with FN after myelotoxic treatment for cancer. Severity of infection was defined according to Bone criteria for severe sepsis and septic shock (SS/SSh) and risk was determined according to Multinational Association of Supportive Care in Cancer (MASCC) criteria. The end point was the implementation of guidelines. Management of patients with SS/SSh required: (i) adequate intravenous (IV) antimicrobial therapy for the first 90 min (broad-spectrum beta-lactam with or without an aminoglycoside); (ii) fluid challenge (500 mL); (iii) lactate measurement; (iv) at least one blood culture; and (v) hospitalization. Management of patients without SS/SSh required: (1) no initiation of granulocyte - cell stimulating factor (G-CSF); (2) adequate IV antimicrobial therapy (broad-spectrum beta-lactam) and hospitalization if the patient was high-risk according to MASCC criteria; (3) adequate oral antimicrobial therapy (quinolone or amoxicillin/clavulanate or cephalosporin) and hospital discharge if the patient was low-risk. RESULTS: 198 patients were enrolled; 89 patients had SS/SSh, of whom 19 received adequate antimicrobial therapy within 90 min and 42 received appropriate fluid challenge. Blood cultures were obtained from 87 and lactate concentration was measured in 29. Overall, only 6 (7%) patients with SS/SSh received adequate management. Among 108 patients without SS/SSh, 38 (35%) were high-risk and 70 (65%) low-risk. In the high-risk group, adequate antimicrobial therapy was given to 31 patients, G-CSF was initiated in 4 and 35 were hospitalized. In the low-risk group, 4 patients received adequate oral antimicrobial therapy, IV antimicrobial therapy was prescribed in 59, G-CSF was initiated in 12 and six patients were discharged. Adequate management was given to 26/38 (68%) high-risk and 1/70 low-risk patients. Factors associated with adequate management were absence of SS/SSh (P = 0.0009) and high-risk according to MASCC criteria (P < 0.0001). CONCLUSIONS: In this French sample of cancer patients presenting to the ED with FN, management was often inadequate and severity was under-evaluated in the critically ill. |
format | Text |
id | pubmed-2887190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28871902010-06-18 Febrile neutropenia in French emergency departments: results of a prospective multicentre survey André, Stéphanie Taboulet, Pierre Elie, Caroline Milpied, Noël Nahon, Michel Kierzek, Gérald Billemont, Mariève Perruche, Franck Charpentier, Sandrine Clément, Hélène Pourriat, Jean-Louis Claessens, Yann-Erick Crit Care Research INTRODUCTION: Febrile neutropenia (FN) is common in cancer patients receiving myelotoxic therapy. The procedures to treat FN are well established in oncology, but it is unclear whether management is adequate in the emergency department (ED). METHODS: This prospective, multicentre, observational study was carried out in 47 French EDs for 6 months. Patients were adults presenting at the ED with FN after myelotoxic treatment for cancer. Severity of infection was defined according to Bone criteria for severe sepsis and septic shock (SS/SSh) and risk was determined according to Multinational Association of Supportive Care in Cancer (MASCC) criteria. The end point was the implementation of guidelines. Management of patients with SS/SSh required: (i) adequate intravenous (IV) antimicrobial therapy for the first 90 min (broad-spectrum beta-lactam with or without an aminoglycoside); (ii) fluid challenge (500 mL); (iii) lactate measurement; (iv) at least one blood culture; and (v) hospitalization. Management of patients without SS/SSh required: (1) no initiation of granulocyte - cell stimulating factor (G-CSF); (2) adequate IV antimicrobial therapy (broad-spectrum beta-lactam) and hospitalization if the patient was high-risk according to MASCC criteria; (3) adequate oral antimicrobial therapy (quinolone or amoxicillin/clavulanate or cephalosporin) and hospital discharge if the patient was low-risk. RESULTS: 198 patients were enrolled; 89 patients had SS/SSh, of whom 19 received adequate antimicrobial therapy within 90 min and 42 received appropriate fluid challenge. Blood cultures were obtained from 87 and lactate concentration was measured in 29. Overall, only 6 (7%) patients with SS/SSh received adequate management. Among 108 patients without SS/SSh, 38 (35%) were high-risk and 70 (65%) low-risk. In the high-risk group, adequate antimicrobial therapy was given to 31 patients, G-CSF was initiated in 4 and 35 were hospitalized. In the low-risk group, 4 patients received adequate oral antimicrobial therapy, IV antimicrobial therapy was prescribed in 59, G-CSF was initiated in 12 and six patients were discharged. Adequate management was given to 26/38 (68%) high-risk and 1/70 low-risk patients. Factors associated with adequate management were absence of SS/SSh (P = 0.0009) and high-risk according to MASCC criteria (P < 0.0001). CONCLUSIONS: In this French sample of cancer patients presenting to the ED with FN, management was often inadequate and severity was under-evaluated in the critically ill. BioMed Central 2010 2010-04-19 /pmc/articles/PMC2887190/ /pubmed/20403164 http://dx.doi.org/10.1186/cc8972 Text en Copyright ©2010 André et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research André, Stéphanie Taboulet, Pierre Elie, Caroline Milpied, Noël Nahon, Michel Kierzek, Gérald Billemont, Mariève Perruche, Franck Charpentier, Sandrine Clément, Hélène Pourriat, Jean-Louis Claessens, Yann-Erick Febrile neutropenia in French emergency departments: results of a prospective multicentre survey |
title | Febrile neutropenia in French emergency departments: results of a prospective multicentre survey |
title_full | Febrile neutropenia in French emergency departments: results of a prospective multicentre survey |
title_fullStr | Febrile neutropenia in French emergency departments: results of a prospective multicentre survey |
title_full_unstemmed | Febrile neutropenia in French emergency departments: results of a prospective multicentre survey |
title_short | Febrile neutropenia in French emergency departments: results of a prospective multicentre survey |
title_sort | febrile neutropenia in french emergency departments: results of a prospective multicentre survey |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887190/ https://www.ncbi.nlm.nih.gov/pubmed/20403164 http://dx.doi.org/10.1186/cc8972 |
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