Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?

Systemic administration of activated protein C (APC) has been shown to reduce pulmonary inflammation in preclinical models of acute lung injury. However, there is only limited information concerning the effects of inhaled APC in modulating the severity of pulmonary inflammation. In a study reported...

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Detalles Bibliográficos
Autor principal: Abraham, Edward
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887193/
https://www.ncbi.nlm.nih.gov/pubmed/20447321
http://dx.doi.org/10.1186/cc8977
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author Abraham, Edward
author_facet Abraham, Edward
author_sort Abraham, Edward
collection PubMed
description Systemic administration of activated protein C (APC) has been shown to reduce pulmonary inflammation in preclinical models of acute lung injury. However, there is only limited information concerning the effects of inhaled APC in modulating the severity of pulmonary inflammation. In a study reported in this issue of Critical Care, Maniatis and colleagues show that pretreatment of mice with inhaled APC is protective against ventilator-induced lung injury. While the mechanisms responsible for this effect require additional elucidation, inhaled APC appears to be a potentially useful intervention in diminishing the severity of ventilator-induced lung injury and other forms of acute lung injury.
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spelling pubmed-28871932011-04-29 Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? Abraham, Edward Crit Care Commentary Systemic administration of activated protein C (APC) has been shown to reduce pulmonary inflammation in preclinical models of acute lung injury. However, there is only limited information concerning the effects of inhaled APC in modulating the severity of pulmonary inflammation. In a study reported in this issue of Critical Care, Maniatis and colleagues show that pretreatment of mice with inhaled APC is protective against ventilator-induced lung injury. While the mechanisms responsible for this effect require additional elucidation, inhaled APC appears to be a potentially useful intervention in diminishing the severity of ventilator-induced lung injury and other forms of acute lung injury. BioMed Central 2010 2010-04-29 /pmc/articles/PMC2887193/ /pubmed/20447321 http://dx.doi.org/10.1186/cc8977 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Commentary
Abraham, Edward
Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
title Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
title_full Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
title_fullStr Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
title_full_unstemmed Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
title_short Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
title_sort inhaled activated protein c: a new therapy for the prevention of ventilator-induced lung injury?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887193/
https://www.ncbi.nlm.nih.gov/pubmed/20447321
http://dx.doi.org/10.1186/cc8977
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