Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
Systemic administration of activated protein C (APC) has been shown to reduce pulmonary inflammation in preclinical models of acute lung injury. However, there is only limited information concerning the effects of inhaled APC in modulating the severity of pulmonary inflammation. In a study reported...
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Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887193/ https://www.ncbi.nlm.nih.gov/pubmed/20447321 http://dx.doi.org/10.1186/cc8977 |
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author | Abraham, Edward |
author_facet | Abraham, Edward |
author_sort | Abraham, Edward |
collection | PubMed |
description | Systemic administration of activated protein C (APC) has been shown to reduce pulmonary inflammation in preclinical models of acute lung injury. However, there is only limited information concerning the effects of inhaled APC in modulating the severity of pulmonary inflammation. In a study reported in this issue of Critical Care, Maniatis and colleagues show that pretreatment of mice with inhaled APC is protective against ventilator-induced lung injury. While the mechanisms responsible for this effect require additional elucidation, inhaled APC appears to be a potentially useful intervention in diminishing the severity of ventilator-induced lung injury and other forms of acute lung injury. |
format | Text |
id | pubmed-2887193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28871932011-04-29 Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? Abraham, Edward Crit Care Commentary Systemic administration of activated protein C (APC) has been shown to reduce pulmonary inflammation in preclinical models of acute lung injury. However, there is only limited information concerning the effects of inhaled APC in modulating the severity of pulmonary inflammation. In a study reported in this issue of Critical Care, Maniatis and colleagues show that pretreatment of mice with inhaled APC is protective against ventilator-induced lung injury. While the mechanisms responsible for this effect require additional elucidation, inhaled APC appears to be a potentially useful intervention in diminishing the severity of ventilator-induced lung injury and other forms of acute lung injury. BioMed Central 2010 2010-04-29 /pmc/articles/PMC2887193/ /pubmed/20447321 http://dx.doi.org/10.1186/cc8977 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Commentary Abraham, Edward Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? |
title | Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? |
title_full | Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? |
title_fullStr | Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? |
title_full_unstemmed | Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? |
title_short | Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? |
title_sort | inhaled activated protein c: a new therapy for the prevention of ventilator-induced lung injury? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887193/ https://www.ncbi.nlm.nih.gov/pubmed/20447321 http://dx.doi.org/10.1186/cc8977 |
work_keys_str_mv | AT abrahamedward inhaledactivatedproteincanewtherapyforthepreventionofventilatorinducedlunginjury |