4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study

INTRODUCTION: Activation of inflammation and coagulation are closely related and mutually interdependent in sepsis. The acute-phase protein, plasminogen activator inhibitor-1 (PAI-1) is a key element in the inhibition of fibrinolysis. Elevated levels of PAI-1 have been related to worse outcome in pn...

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Detalles Bibliográficos
Autores principales: Madách, Krisztina, Aladzsity, István, Szilágyi, Ágnes, Fust, George, Gál, János, Pénzes, István, Prohászka, Zoltán
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887202/
https://www.ncbi.nlm.nih.gov/pubmed/20429897
http://dx.doi.org/10.1186/cc8992

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