Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats

The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg(−1) b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Vishnu, Khan, Mohammad Mubin, Khanna, Ashok Kumar, Singh, Ranjana, Singh, Sushma, Chander, Ramesh, Mahdi, Farzana, Mahdi, Abbas Ali, Saxena, Jitendra Kumar, Singh, Raj Kumar
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Original Articles - Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887325/
https://www.ncbi.nlm.nih.gov/pubmed/18955320
http://dx.doi.org/10.1093/ecam/nen001
Descripción
Sumario:The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg(−1) b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.

Ejemplares similares