Cargando…

BMP-2/6 Heterodimer Is More Effective than BMP-2 or BMP-6 Homodimers as Inductor of Differentiation of Human Embryonic Stem Cells

BACKGROUND: Bone Morphogenetic Protein (BMP) signaling pathways are involved in differentiation of stem cells into diverse cell types, and thus BMPs can be used as main guidance molecules for in vitro differentiation of human stem cells. METHODOLOGY/PRINCIPAL FINDINGS: We have analyzed the ability f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valera, Elvira, Isaacs, Michael J., Kawakami, Yasuhiko, Izpisúa Belmonte, Juan Carlos, Choe, Senyon
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887366/ https://www.ncbi.nlm.nih.gov/pubmed/20567515 http://dx.doi.org/10.1371/journal.pone.0011167

Ejemplares similares

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis
por: Kim, Hyung-Seok, et al.
Publicado: (2019)

Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers
por: Gipson, Gregory R., et al.
Publicado: (2023)

Fibrin Hydrogel Based Bone Substitute Tethered with BMP-2 and BMP-2/7 Heterodimers
por: Karfeld-Sulzer, Lindsay S., et al.
Publicado: (2015)

Activin A/BMP2 Chimera (AB204) Exhibits Better Spinal Bone Fusion Properties than rhBMP2
por: Ryu, Dalsung, et al.
Publicado: (2018)

BMP6 Mediates BMP2-Increased Human Trophoblast Invasion
por: Deng, Jianye, et al.
Publicado: (2021)

Diverse effect of BMP-2 homodimer on mesenchymal progenitors of different origin
por: Hrubi, Edit, et al.
Publicado: (2018)

Expression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeleton
por: Kochanowska, Iwona, et al.
Publicado: (2007)

Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis
por: Bandyopadhyay, Amitabha, et al.
Publicado: (2006)

Copresentation of BMP-6 and RGD Ligands Enhances Cell Adhesion and BMP-Mediated Signaling
por: Posa, Francesca, et al.
Publicado: (2019)

Single Cell Center of Mass for the Analysis of BMP Receptor Heterodimers Distributions
por: Boog, Hendrik, et al.
Publicado: (2021)

BMP-2 and BMP-2/7 Heterodimers Conjugated to a Fibrin/Hyaluronic Acid Hydrogel in a Large Animal Model of Mild Intervertebral Disc Degeneration
por: Peeters, Mirte, et al.
Publicado: (2015)

Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development
por: Xue, Yu, et al.
Publicado: (2014)

Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
por: Berasi, Stephen P, et al.
Publicado: (2011)

Agrin Binds BMP2, BMP4 and TGFβ1
por: Bányai, László, et al.
Publicado: (2010)

BMP heterodimers signal via distinct type I receptor class functions
por: Tajer, Benjamin, et al.
Publicado: (2021)

Bmp2, Bmp4 and Bmp7 Are Co-Required in the Mouse AER for Normal Digit Patterning but Not Limb Outgrowth
por: Choi, Kyung-Suk, et al.
Publicado: (2012)

Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors
por: Pi, Xinchun, et al.
Publicado: (2007)

Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors
por: Pi, Xinchun, et al.
Publicado: (2009)

Reconstruction of radial bone defect using gelatin sponge and a BMP-2 combination graft
por: Kim, Seong-Gon, et al.
Publicado: (2013)

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum
por: Herrera, Blanca, et al.
Publicado: (2009)

BMP heterodimers assemble hetero-type I receptor complexes that pattern the DV axis
por: Little, Shawn C., et al.
Publicado: (2009)

Asymmetric paralog evolution between the “cryptic” gene Bmp16 and its well-studied sister genes Bmp2 and Bmp4
por: Feiner, Nathalie, et al.
Publicado: (2019)

The BMP2 nuclear variant, nBMP2, is expressed in mouse hippocampus and impacts memory
por: Cordner, Ryan D., et al.
Publicado: (2017)

Site pleiotropy of a stickleback Bmp6 enhancer
por: Rowley, Alyssa J., et al.
Publicado: (2022)

Assessment of plasma BMP-2, BMP-7, BMP-10, vitamin D, and TGF β1 in simple fractures among Sudanese patients
por: Ali, Amin Ahmed, et al.
Publicado: (2021)

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway
por: Enns, Caroline A., et al.
Publicado: (2013)

IL-6 Regulates Hepcidin Expression Via the BMP/SMAD Pathway by Altering BMP6, TMPRSS6 and TfR2 Expressions at Normal and Inflammatory Conditions in BV2 Microglia
por: Varga, Edit, et al.
Publicado: (2021)

An Activin A/BMP2 chimera, AB215, blocks estrogen signaling via induction of ID proteins in breast cancer cells
por: Jung, Jae Woo, et al.
Publicado: (2014)

Temporal regulation of mRNAs for select bone morphogenetic proteins (BMP), BMP receptors and their associated SMAD proteins during bovine early embryonic development: effects of exogenous BMP2 on embryo developmental progression
por: Lee, Kyung-Bon, et al.
Publicado: (2014)

Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia
por: Tillet, Emmanuelle, et al.
Publicado: (2015)

Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes
por: Jiménez, G., et al.
Publicado: (2015)

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway
por: Kopf, Jessica, et al.
Publicado: (2012)

Immunohistological Localization of BMP-2, BMP-7, and Their Receptors in Knee Joints with Focal Cartilage Lesions
por: Schmal, Hagen, et al.
Publicado: (2012)

The effect of trace elements on BMP-2, BMP-7 and STRO-1(+) cells in hip replacement
por: Fu, Xiaodong, et al.
Publicado: (2020)

Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling
por: Karim, Md. Shahriar, et al.
Publicado: (2021)

Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression
por: Kawai, Mariko, et al.
Publicado: (2006)

Specification of BMP Signaling
por: Nickel, Joachim, et al.
Publicado: (2019)

Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer
por: Tomlinson, Ian P. M., et al.
Publicado: (2011)

Sox9 Potentiates BMP2-Induced Chondrogenic Differentiation and Inhibits BMP2-Induced Osteogenic Differentiation
por: Liao, Junyi, et al.
Publicado: (2014)

A Cyclic BMP-2 Peptide Upregulates BMP-2 Protein-Induced Cell Signaling in Myogenic Cells
por: Gudivada, Vijaya Narasimha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bj563q5uric6uju6kraauo18lh