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Fast- or Slow-inactivated State Preference of Na(+) Channel Inhibitors: A Simulation and Experimental Study

Sodium channels are one of the most intensively studied drug targets. Sodium channel inhibitors (e.g., local anesthetics, anticonvulsants, antiarrhythmics and analgesics) exert their effect by stabilizing an inactivated conformation of the channels. Besides the fast-inactivated conformation, sodium...

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Detalles Bibliográficos
Autores principales:	Karoly, Robert, Lenkey, Nora, Juhasz, Andras O., Vizi, E. Sylvester, Mike, Arpad
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887460/ https://www.ncbi.nlm.nih.gov/pubmed/20585544 http://dx.doi.org/10.1371/journal.pcbi.1000818

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