TARGETING IL-23: INSIGHTS INTO THE PATHOGENESIS AND THE TREATMENT OF PSORIASIS

Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis. Studies with anti-IL-12/23 therapeutic agents, which act in different steps of the psoriatic inflammatory cascade, have also shown demonstrable ef...

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Detalles Bibliográficos
Autores principales: Lima, Hermenio Cavalcante, Kimball, Alexandra Boer
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
IJD Symposium
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887523/
https://www.ncbi.nlm.nih.gov/pubmed/20606888
http://dx.doi.org/10.4103/0019-5154.62760
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author Lima, Hermenio Cavalcante
Kimball, Alexandra Boer
author_facet Lima, Hermenio Cavalcante
Kimball, Alexandra Boer
author_sort Lima, Hermenio Cavalcante
collection PubMed
description Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis. Studies with anti-IL-12/23 therapeutic agents, which act in different steps of the psoriatic inflammatory cascade, have also shown demonstrable efficacy. Here, we discuss this approach and its potential within the armamentarium for the treatment of psoriasis. Evidences that the selective blocking of IL-23 may be effective and safe therapy are also addressed.
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spelling pubmed-28875232010-07-02 TARGETING IL-23: INSIGHTS INTO THE PATHOGENESIS AND THE TREATMENT OF PSORIASIS Lima, Hermenio Cavalcante Kimball, Alexandra Boer Indian J Dermatol IJD Symposium Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis. Studies with anti-IL-12/23 therapeutic agents, which act in different steps of the psoriatic inflammatory cascade, have also shown demonstrable efficacy. Here, we discuss this approach and its potential within the armamentarium for the treatment of psoriasis. Evidences that the selective blocking of IL-23 may be effective and safe therapy are also addressed. Medknow Publications 2010 /pmc/articles/PMC2887523/ /pubmed/20606888 http://dx.doi.org/10.4103/0019-5154.62760 Text en © Indian Journal of Dermatology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle IJD Symposium
Lima, Hermenio Cavalcante
Kimball, Alexandra Boer
TARGETING IL-23: INSIGHTS INTO THE PATHOGENESIS AND THE TREATMENT OF PSORIASIS
title TARGETING IL-23: INSIGHTS INTO THE PATHOGENESIS AND THE TREATMENT OF PSORIASIS
title_full TARGETING IL-23: INSIGHTS INTO THE PATHOGENESIS AND THE TREATMENT OF PSORIASIS
title_fullStr TARGETING IL-23: INSIGHTS INTO THE PATHOGENESIS AND THE TREATMENT OF PSORIASIS
title_full_unstemmed TARGETING IL-23: INSIGHTS INTO THE PATHOGENESIS AND THE TREATMENT OF PSORIASIS
title_short TARGETING IL-23: INSIGHTS INTO THE PATHOGENESIS AND THE TREATMENT OF PSORIASIS
title_sort targeting il-23: insights into the pathogenesis and the treatment of psoriasis
topic IJD Symposium
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887523/
https://www.ncbi.nlm.nih.gov/pubmed/20606888
http://dx.doi.org/10.4103/0019-5154.62760
work_keys_str_mv AT limahermeniocavalcante targetingil23insightsintothepathogenesisandthetreatmentofpsoriasis
AT kimballalexandraboer targetingil23insightsintothepathogenesisandthetreatmentofpsoriasis

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