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Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer

BACKGROUND: Telomerase is activated in oncogenesis, which confers an immortal phenotype to cancer cells. The AAA + ATPase Reptin is required for telomerase biogenesis by maintaining telomerase RNA (hTER) stability and is aberrantly expressed in certain cancers. Given its role in chromatin remodeling...

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Detalles Bibliográficos
Autores principales:	Li, Wenjuan, Zeng, Jiping, Li, Qiao, Zhao, Li, Liu, Tiantian, Björkholm, Magnus, Jia, Jihui, Xu, Dawei
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887797/ https://www.ncbi.nlm.nih.gov/pubmed/20509972 http://dx.doi.org/10.1186/1476-4598-9-132

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