A Novel, Single Algorithm Approach to Predict Acenocoumarol Dose Based on CYP2C9 and VKORC1 Allele Variants

The identification of CYP2C9 and VKORC1 genes has strongly stimulated the research on pharmacogenetics of coumarins in the last decade. We assessed the combined influence of CYP2C9 *2 and *3, and VKORC1 c.-1639G>A, 497C>G, and 1173C>T variants, on acenocoumarol dosage using a novel algorith...

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Detalles Bibliográficos
Autores principales: Verde, Zoraida, Ruiz, Jonatan R., Santiago, Catalina, Valle, Beatriz, Bandrés, Fernando, Calvo, Elpidio, Lucía, Alejandro, Gallego, Félix Gómez
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887839/
https://www.ncbi.nlm.nih.gov/pubmed/20585445
http://dx.doi.org/10.1371/journal.pone.0011210

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