Downregulation of Homologous Recombination DNA Repair Genes by HDAC Inhibition in Prostate Cancer Is Mediated through the E2F1 Transcription Factor

BACKGROUND: Histone deacetylase inhibitors (HDACis) re-express silenced tumor suppressor genes and are currently undergoing clinical trials. Although HDACis have been known to induce gene expression, an equal number of genes are downregulated upon HDAC inhibition. The mechanism behind this downregul...

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Detalles Bibliográficos
Autores principales: Kachhap, Sushant K., Rosmus, Nadine, Collis, Spencer J., Kortenhorst, Madeleine S. Q., Wissing, Michel D., Hedayati, Mohammad, Shabbeer, Shabana, Mendonca, Janet, Deangelis, Justin, Marchionni, Luigi, Lin, Jianqing, Höti, Naseruddin, Nortier, Johan W. R., DeWeese, Theodore L., Hammers, Hans, Carducci, Michael A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887841/
https://www.ncbi.nlm.nih.gov/pubmed/20585447
http://dx.doi.org/10.1371/journal.pone.0011208

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