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Anomalous DNA binding by E2 regulatory protein driven by spacer sequence TATA

We have investigated the anomalously weak binding of human papillomavirus (HPV) regulatory protein E2 to a DNA target containing the spacer sequence TATA. Experiments in magnesium (Mg(2+)) and calcium (Ca(2+)) ion buffers revealed a marked reduction in cutting by DNase I at the CpG sequence in the p...

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Detalles Bibliográficos
Autores principales:	Xi, Zhiqun, Zhang, Yongli, Hegde, Rashmi S., Shakked, Zippora, Crothers, Donald M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887970/ https://www.ncbi.nlm.nih.gov/pubmed/20185566 http://dx.doi.org/10.1093/nar/gkq114

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